Macrophage abundance in oncocytic thyroid cancer is associated with PD-L1 expression
The heightened metabolic activity and reduced differentiation of OTC revealed by our transcriptional studies correlate with clinical features such as FDG-PET avidity and diminished RAI response. Marked PD-L1 upregulation in widely invasive OTC suggests immune checkpoint inhibition as a potential therapeutic strategy. Larger, independent studies will be critical to validate these findings.
Authors
- Caitlin Caperton
- Julio C. Ricarte‐Filho (ORCID: https://orcid.org/0000-0002-8427-6869)
- Nicole Massoll
- Aime T. Franco (ORCID: https://orcid.org/0000-0002-1677-5228)
- Amber Isaza (ORCID: https://orcid.org/0000-0003-0863-7500)
Institutions
- Children's Hospital of Philadelphia (US)
- Winthrop Rockefeller Foundation (US)
- University of Pennsylvania (US)
- University of Arkansas for Medical Sciences (US)
Publication Details
- Journal
- Endocrine Oncology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1530/eo-25-0026
- Primary Topic
- Thyroid Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00