Fecal microbiota transplantation alleviated heat-induced colonic tissue damage, epithelial apoptosis, and oxidative stress
This study is the first to demonstrate the protective role of fecal microbiota transplantation (FMT) against heat-induced colonic injury in a mouse model. We show that FMT mitigates colonic damage by restoring gut microbiota balance, preserving mucosal barrier integrity, inhibiting epithelial cell apoptosis, and reducing oxidative stress. These findings underscore the essential role of the gut microbiota in maintaining intestinal homeostasis under heat stress and highlight the therapeutic potential of microbiota-targeted strategies, such as FMT, in preventing or treating heat-related intestinal injury.
Authors
- Qingxian Wang (ORCID: https://orcid.org/0009-0002-5910-0965)
- Li Na Zhang (ORCID: https://orcid.org/0000-0003-0531-7624)
- Cuiqing Liu (ORCID: https://orcid.org/0000-0002-0393-7806)
- Shiqing Zhang
- Qianhan Shi
- Wenwen Yang (ORCID: https://orcid.org/0000-0002-6027-7816)
- Qinghua Sun (ORCID: https://orcid.org/0000-0002-7985-103X)
- Yanxi Chai
- Chuchu Liu (ORCID: https://orcid.org/0000-0002-7530-9489)
- Xiang Zeng (ORCID: https://orcid.org/0000-0001-8252-3558)
- Xiaoli Qian
- Xiyu Liu (ORCID: https://orcid.org/0009-0003-0662-1465)
- Yue Wu (ORCID: https://orcid.org/0009-0003-2116-3837)
- Zhenghong Yao
Institutions
- Zhejiang Chinese Medical University (CN)
- Japan International Cooperation Agency (JP)
- China International Science and Technology Cooperation (CN)
Publication Details
- Journal
- Applied and Environmental Microbiology
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1128/aem.00976-25
- Citations
- 2
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 1.61