Effect of aging on biomarkers and clinical profile in Parkinson’s disease
Our data support the hypothesis that PD has different underlying biological features in younger and older subjects. Older subjects may have a broader spectrum of disease mechanisms, reflected in the higher prevalence of amyloid pathology and neurodegeneration, which could underlie the worse cognitive performances and lower dyskinesia burden. They could therefore necessitate a wider array of treatment strategies along with dopaminergic supplementation. Consequently, some of these biomarkers hold promise in refining treatment approaches in PD.
Authors
- Guido Maria Giuffrè (ORCID: https://orcid.org/0000-0002-7271-1229)
- Piergiorgio Grillo (ORCID: https://orcid.org/0000-0001-8196-3914)
- Lucilla Parnetti (ORCID: https://orcid.org/0000-0001-5722-3967)
- Giulia Di Lazzaro (ORCID: https://orcid.org/0000-0003-2413-1788)
- Anna Rita Bentivoglio (ORCID: https://orcid.org/0000-0002-9663-095X)
- Tommaso Schirinzi (ORCID: https://orcid.org/0000-0002-2517-6278)
- Federico Paolini Paoletti (ORCID: https://orcid.org/0000-0001-9623-1900)
- Anna Picca (ORCID: https://orcid.org/0000-0001-7032-3487)
- Giovanni Bellomo (ORCID: https://orcid.org/0000-0003-0456-5650)
- Nicola Biagio Mercuri (ORCID: https://orcid.org/0000-0001-6700-7491)
- Paolo Calabresi (ORCID: https://orcid.org/0000-0003-0326-5509)
- Martina Petracca (ORCID: https://orcid.org/0000-0001-8033-3785)
Institutions
- Università Cattolica del Sacro Cuore (IT)
- University of Rome Tor Vergata (IT)
- University of Pavia (IT)
- University of Perugia (IT)
- Agostino Gemelli University Polyclinic (IT)
- LUM Jean Monnet University (IT)
Publication Details
- Journal
- Journal of Neurology
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1007/s00415-025-13384-7
- Citations
- 3
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.17
Funders
- Ministero dell’Istruzione, dell’Università e della Ricerca