Determinants of successful smoking cessation in outpatient settings: A comparative analysis of varenicline and free program interventions

Varenicline use, specific sociodemographic characteristics (aged >50 years, married, full-time employment), and less severe smoking behavior (≤20 cigarettes/day, ≤25 years duration, ≤600 pack-year) are key determinants of successful smoking cessation in outpatient settings. Varenicline use was associated with significantly higher cessation rates compared to bupropion within both intervention models. The free program incorporating varenicline (B2) demonstrated particularly high success rates.