Palmitoyl‐Protein Thioesterase 1 (PPT1) Protein, Linked to Neuronal Ceroid Lipofuscinosis 1, Is a Major Constituent of Ageing‐Related Human Neuronal Lipofuscin
Proteomics of laser-dissected lipofuscin from aged, healthy brains reveals Palmitoyl-Protein Thioesterase 1 (PPT1) and other CLN proteins as constituents. PPT1 is increasingly sequestered to lipofuscin during ageing. Protein sequestering into lipofuscin may contribute to physiological neuronal ageing.
Authors
- Steffen Kösters (ORCID: https://orcid.org/0000-0001-6972-0653)
- Eleonora Aronica (ORCID: https://orcid.org/0000-0002-3542-3770)
- Sarah K. Tschirner (ORCID: https://orcid.org/0009-0007-4972-9811)
- Katrin Marcus (ORCID: https://orcid.org/0000-0002-3313-8845)
- Max Anstötz (ORCID: https://orcid.org/0000-0003-3071-5835)
- Svenja Caspers (ORCID: https://orcid.org/0000-0001-5083-4669)
- Caroline May (ORCID: https://orcid.org/0000-0002-6532-5979)
- Carsten Korth (ORCID: https://orcid.org/0000-0003-1503-1822)
- Christine Martin
- Hans J. Bidmon
Institutions
- Forschungszentrum Jülich (DE)
- University Hospitals of the Ruhr-University of Bochum (DE)
- Düsseldorf University Hospital (DE)
- Amsterdam Neuroscience (NL)
- Amsterdam University Medical Centers (NL)
- Heinrich Heine University Düsseldorf (DE)
- University of Amsterdam (NL)
- Ruhr University Bochum (DE)
Publication Details
- Journal
- Neuropathology and Applied Neurobiology
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1111/nan.70043
- Citations
- 2
- Primary Topic
- Ubiquitin and proteasome pathways
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Bundesministerium für Bildung und Forschung