ALPPS surgery induces macroscopic division of labor with metabolic lobe support to accelerate liver regeneration – experimental studies
LLs act as auxiliary livers after ALPPS, enabling the FLR to focus on growth. Our findings demonstrate the functional requirement for division of labor during regeneration. This transient division roots on plastic behavior of the different lobes during ALPPS regeneration and reveals how metabolic needs define the liver's regenerative capacity.
Authors
- Bostjan Humar (ORCID: https://orcid.org/0000-0002-7956-3062)
- Dominique Lisa Birrer (ORCID: https://orcid.org/0000-0002-4305-0265)
- Pierre–Alain Clavien (ORCID: https://orcid.org/0000-0002-9916-7905)
- U. Ungethüm
- Jae–Hwi Jang
- S Molina Guerra
Institutions
- University of Fribourg (CH)
- University Hospital of Zurich (CH)
- Krankenhaus Bethanien (DE)
- Metropolitan University (BD)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2025-09-22
- DOI
- https://doi.org/10.1097/js9.0000000000003216
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00