Enflicoxib for the long-term management of canine osteoarthritis—External validation of a population pharmacokinetic model in dogs with osteoarthritis

The established popPK model in healthy Beagle dogs can predict the PK behavior of enflicoxib and its pyrazol metabolite in dogs of any breed with OA. The lack of time-dependent PK provides a PK rationale to support continuous enflicoxib treatment for as long as therapeutically required.

Authors

Josep Homedes (ORCID: https://orcid.org/0000-0001-5440-7699)
José Miguel Vela (ORCID: https://orcid.org/0000-0002-6809-1477)
Gregorio Encina (ORCID: https://orcid.org/0000-0001-5953-8911)
Marta Salichs (ORCID: https://orcid.org/0000-0003-2456-0726)
J. M. Cendros

Institutions

Veterinarians Without Borders (US)
Universitat de Barcelona (ES)

Publication Details

Journal: Frontiers in Veterinary Science
Published: 2025-09-24
DOI: https://doi.org/10.3389/fvets.2025.1645857
Primary Topic: Veterinary Orthopedics and Neurology
Type: article
Field-Weighted Citation Impact: 0.00

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article

Enflicoxib for the long-term management of canine osteoarthritis—External validation of a population pharmacokinetic model in dogs with osteoarthritis

Josep Homedes, José Miguel Vela, Gregorio Encina, Marta Salichs et al.

Sep 24, 2025

Frontiers in Veterinary Science

Veterinary Orthopedics and Neurology

article

Enflicoxib for the long-term management of canine osteoarthritis—External validation of a population pharmacokinetic model in dogs with osteoarthritis

Josep Homedes, José Miguel Vela, Gregorio Encina, Marta Salichs, J. M. Cendros

September 24, 2025article en

Abstract

The established popPK model in healthy Beagle dogs can predict the PK behavior of enflicoxib and its pyrazol metabolite in dogs of any breed with OA. The lack of time-dependent PK provides a PK rationale to support continuous enflicoxib treatment for as long as therapeutically required.

Frontiers in Veterinary ScienceVol. 12

Veterinarians Without Borders (US), Universitat de Barcelona (ES)

Openalex Percentile: Top 72%

Veterinary Orthopedics and Neurology

DOI Open Access PDF OpenAlex

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