<scp>DSOK</scp> ‐0011 Potentially Regulates Circadian Misalignment and Affects Gut Microbiota Composition in Activity‐Based Anorexia Model
Inhibition of 11β-HSD1 by DSOK-0011 was associated with microbiota alterations and subtle shifts in activity timing under energy-deficient conditions. These findings suggest that peripheral glucocorticoid metabolism may influence microbial and behavioral responses in the ABA model, although its metabolic impact appears limited in the acute phase.
Authors
- T. KATO (ORCID: https://orcid.org/0000-0001-6166-2698)
- Hiroki Kawai (ORCID: https://orcid.org/0000-0002-4441-9896)
- Toshitaka Oohashi (ORCID: https://orcid.org/0000-0002-9302-1913)
- Yoshihiro Horiuchi
- Yuko Okahisa (ORCID: https://orcid.org/0000-0003-1125-0761)
- Kenji Hinotsu
- Shinji Sakamoto (ORCID: https://orcid.org/0000-0001-5498-551X)
- Hung Nguyen (ORCID: https://orcid.org/0000-0002-6662-4495)
- Takahiro Asada (ORCID: https://orcid.org/0000-0002-3227-8045)
- Naoko Wada (ORCID: https://orcid.org/0000-0001-6916-3025)
- Kenji Miyazaki
- Yoshio Ohya
- Manabu Takaki
- Haruko Miyazaki
- Akiyoshi Yokode
- Hiroshi Kirii
Institutions
- Okayama University of Science (JP)
- Okayama University (JP)
- Sumitomo Dainippon Pharma (Japan) (JP)
- Okayama University Hospital (JP)
Publication Details
- Journal
- International Journal of Eating Disorders
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1002/eat.24557
- Primary Topic
- Stress Responses and Cortisol
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science