Four-Factor Prothrombin Complex Concentrate Administration Timing in Oral Anticoagulant-Associated Intracranial Hemorrhage
Time to 4F-PCC administration was not associated with 48-hour hematoma expansion or mortality in patients with OAC-associated ICH. These results may reflect delayed administration, as 4F-PCC may not have been administered early enough to influence outcomes. Further research is warranted to evaluate the clinical impact of 4F-PCC administration timing.
Authors
- Hui‐Jie Lee (ORCID: https://orcid.org/0000-0002-6060-8443)
- Shawn Kram (ORCID: https://orcid.org/0000-0001-5532-0384)
- Jana Sigmon (ORCID: https://orcid.org/0000-0001-5847-0871)
- Jennifer M. Schultheis (ORCID: https://orcid.org/0000-0002-4280-7326)
- Michael J. Scott (ORCID: https://orcid.org/0000-0002-5898-225X)
- Keith Dombrowski (ORCID: https://orcid.org/0000-0002-2469-7071)
Institutions
- Beth Israel Deaconess Medical Center (US)
- Duke University (US)
- University of South Florida (US)
- Tampa General Hospital (US)
- Novant Health Presbyterian Medical Center (US)
- Duke University Hospital (US)
Publication Details
- Journal
- Hospital Pharmacy
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1177/00185787251372052
- Primary Topic
- Intracerebral and Subarachnoid Hemorrhage Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00