Causal associations of specific immunoglobulin G N-glycosylation subtypes with osteoporosis: A two-sample Mendelian randomization
Our study results indicate that IgG45 contributes positively to osteoporosis, whereas IgG4 and IgG56 exhibit a negative correlation. Nonetheless, additional research is crucial to understand their mechanisms and devise broader preventive strategies for osteoporosis.
Authors
- Chaoyun Yuan (ORCID: https://orcid.org/0000-0002-4182-0908)
- Lijuan Wang (ORCID: https://orcid.org/0000-0002-0864-8229)
- Lijun Wang (ORCID: https://orcid.org/0009-0004-2954-3049)
- Yimiao Zhu (ORCID: https://orcid.org/0000-0002-1745-4063)
- Yu Zhao (ORCID: https://orcid.org/0000-0002-3904-4276)
- Chenyan Yan (ORCID: https://orcid.org/0000-0002-0328-4964)
- Wei Zhang (ORCID: https://orcid.org/0000-0003-0459-5382)
Institutions
- Hangzhou Medical College (CN)
Publication Details
- Journal
- Joint Diseases and Related Surgery
- Published
- 2025-09-23
- DOI
- https://doi.org/10.52312/jdrs.2026.2361
- Primary Topic
- Glycosylation and Glycoproteins Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Department of Education of Zhejiang Province
- Medical Science and Technology Project of Zhejiang Province
- Science and Technology Program of Zhejiang Province