Topical Application of Everolimus Attenuates Lens-Induced Myopia Through mTORC1 Suppression
This novel ophthalmic formulation effectively delivered everolimus to the posterior segment and inhibited myopia progression, supporting its clinical potential for myopia control.
Authors
- Ruiheng Zhang (ORCID: https://orcid.org/0000-0002-1324-4739)
- Bingyu Cai (ORCID: https://orcid.org/0000-0002-2016-2352)
- Wen‐Da Zhou
- Yuhang Yang (ORCID: https://orcid.org/0000-0002-3355-6166)
- Jiaoyue Dong
- Xu‐Han Shi
- Haotian Wu (ORCID: https://orcid.org/0000-0002-6271-0249)
- Chuyao Yu
- Hanqing Zhao (ORCID: https://orcid.org/0000-0003-0327-3699)
- Jost Bruno Jonas (ORCID: https://orcid.org/0000-0003-2972-5227)
- Wei Li (ORCID: https://orcid.org/0000-0002-9991-7892)
- Shanshan Wang (ORCID: https://orcid.org/0000-0001-7364-768X)
- Yitong Li (ORCID: https://orcid.org/0000-0003-4432-2936)
- Lei Shao (ORCID: https://orcid.org/0000-0001-6776-9787)
- Wenbin Wei (ORCID: https://orcid.org/0000-0003-2386-0989)
- Li Dong (ORCID: https://orcid.org/0000-0003-2623-3198)
Institutions
- Beijing Tongren Hospital (CN)
- Capital Medical University (CN)
- Chinese Academy of Sciences (CN)
- Singapore National Eye Center (SG)
- L V Prasad Eye Institute (IN)
- Singapore Eye Research Institute (SG)
- Fondation de Rothschild (FR)
- Beijing Tsinghua Chang Gung Hospital (CN)
- University of Chinese Academy of Sciences (CN)
- Institute of Zoology (CN)
- State Key Laboratory of Stem Cell and Reproductive Biology
- Ministry of Industry and Information Technology (CN)
- Tsinghua University (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1167/iovs.66.12.55
- Primary Topic
- Ophthalmology and Visual Impairment Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00