When new therapies meet old challenges: tirzepatide–warfarin interaction in a mechanical mitral valve patient

Tirzepatide may indirectly affect the pharmacokinetics of warfarin.In patients receiving both warfarin and tirzepatide, closer INR monitoring may be required.Careful attention to potential drug interactions is warranted, even when no direct interaction is known.

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Publication Details

Journal
European Journal of Case Reports in Internal Medicine
Published
2025-09-24
DOI
https://doi.org/10.12890/2025_005823
Primary Topic
Cardiovascular Function and Risk Factors
Type
article
Field-Weighted Citation Impact
0.00
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article

When new therapies meet old challenges: tirzepatide–warfarin interaction in a mechanical mitral valve patient

Fabrizio Pasanisi, Luca Maria Capece, Ermenegilda Pagano, Sofia Donnarumma et al.
European Journal of Case Reports in Internal Medicine
Cardiovascular Function and Risk Factors
article

When new therapies meet old challenges: tirzepatide–warfarin interaction in a mechanical mitral valve patient

Fabrizio Pasanisi, Luca Maria Capece, Ermenegilda Pagano, Sofia Donnarumma, Lidia Santarpia, Annadora Morena, Raffaele Natale
article en

Abstract

Tirzepatide may indirectly affect the pharmacokinetics of warfarin.In patients receiving both warfarin and tirzepatide, closer INR monitoring may be required.Careful attention to potential drug interactions is warranted, even when no direct interaction is known.

European Journal of Case Reports in Internal MedicineVol. 12(10)
Casa di Cura Villa Pini d’Abruzzo (IT), Federico II University Hospital (IT)
Openalex Percentile: Top 60%
Cardiovascular Function and Risk Factors
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