MEN1 Promotes Ferroptosis by Disrupting CD44 Alternative Splicing to Suppress Lung Cancer
MEN1 governs CD44 alternative splicing and CD44 variant generation to activate ferroptosis and disrupt lung cancer development, highlighting the potential of targeting this axis to treat MEN1-deficient tumors.
Authors
- Qianting Tian (ORCID: https://orcid.org/0009-0000-0913-5305)
- Z J Wang (ORCID: https://orcid.org/0009-0005-0488-1292)
- Bangming Jin
- Tengxiang Chen (ORCID: https://orcid.org/0000-0001-6907-1374)
- Xuyan Wang
- Houmei Wang (ORCID: https://orcid.org/0000-0003-1739-1338)
- Bing Guo (ORCID: https://orcid.org/0000-0001-8998-2597)
- Chaochun Chen (ORCID: https://orcid.org/0000-0002-1028-1331)
- Tuo Zhang (ORCID: https://orcid.org/0000-0003-3256-5930)
- Y.H.F. Teng
- Guixue Dan
- Pan Ting (ORCID: https://orcid.org/0009-0008-2504-7426)
- M L Liu
- Dekun Tang (ORCID: https://orcid.org/0009-0008-4599-5570)
- Y. Yang
- Jiamei Zhu
- D. Yu
Institutions
- Guiyang Medical University (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1158/0008-5472.can-25-0021
- Citations
- 1
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China
- Anhui Medical University
- Huaqiao University
- Guizhou Medical University
- National Cancer Institute