Integrative single-cell and machine learning approach to characterize immunogenic cell death and tumor microenvironment in LUAD
This study highlights the crucial role of ICD in LUAD immune regulation and prognosis. The ICDRS serves as a robust biomarker for risk stratification and immunotherapy guidance, while SLC2A1 emerges as a potential therapeutic target to augment immunotherapeutic efficacy.
Authors
- Xiaoteng Jia (ORCID: https://orcid.org/0000-0001-5630-8838)
- Xiaojiang Zhao
- Xin Li (ORCID: https://orcid.org/0000-0003-2525-9679)
- Han Zhang (ORCID: https://orcid.org/0000-0001-8498-3451)
- Kai You Wang (ORCID: https://orcid.org/0000-0002-6170-4744)
- Yuhang Jiang (ORCID: https://orcid.org/0009-0003-6570-245X)
- Daqiang Sun (ORCID: https://orcid.org/0009-0000-6602-357X)
- Qiuqiao Mu
Institutions
- Tianjin University (CN)
- Tianjin Chest Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1186/s12967-025-06889-2
- Citations
- 6
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 6.27