Reduced synaptic vesicle protein 2A in extracellular vesicles and brains of Alzheimer’s disease: associations with Aβ, tau, synaptic proteins and APOE ε4
SV2A levels in brain tissues and BDEVs are reduced in AD patients, particularly in those carrying the APOE ε4 allele, and are correlated with Aβ and tau pathologies. SV2A may serve as a valuable biomarker for monitoring synaptic dysfunction and progression in AD.
Authors
- Morvane Colin (ORCID: https://orcid.org/0000-0003-0611-4167)
- J. C. Nussbaumer
- Aatmika Barve (ORCID: https://orcid.org/0000-0003-2331-5825)
- Kevin Richetin (ORCID: https://orcid.org/0000-0001-7859-9517)
- Uwe Konietzko (ORCID: https://orcid.org/0000-0002-6897-232X)
- Tunahan Kirabali (ORCID: https://orcid.org/0000-0002-7554-3371)
- Ruiqing Ni (ORCID: https://orcid.org/0000-0002-0793-2113)
- Luc Buée (ORCID: https://orcid.org/0000-0002-6261-4230)
- Valentin Zufferey (ORCID: https://orcid.org/0009-0005-3393-9246)
- Axel Rominger (ORCID: https://orcid.org/0000-0002-1954-736X)
- Jeanne Espourteille (ORCID: https://orcid.org/0000-0002-1742-0779)
- Daniel Razansky (ORCID: https://orcid.org/0000-0001-8676-0964)
- Agneta Nordberg (ORCID: https://orcid.org/0000-0001-7345-5151)
- Roger M. Nitsch
- Christoph Höck
Institutions
- Inserm (FR)
- University of Zurich (CH)
- Université de Lille (FR)
- Institut Pasteur de Lille (FR)
- University Hospital of Bern (CH)
- Centre Hospitalier Universitaire Vaudois (CH)
- Karolinska Institutet (SE)
- Centre Hospitalier Universitaire de Lille (FR)
- Institute for Biomedical Engineering (CH)
- Swiss Institute for Regenerative Medicine (CH)
- Light Chain Bioscience (Switzerland) (CH)
- University of Lausanne (CH)
Publication Details
- Journal
- Translational Neurodegeneration
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1186/s40035-025-00508-2
- Citations
- 5
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 5.82
Funders
- Eidgenössische Technische Hochschule Zürich
- Université de Lausanne
- Centre Hospitalier Universitaire Vaudois
- Universität Zürich