TYK2 Promotes Immunosurveillance of Colorectal Cancer Liver Metastasis
TYK2 restricts the metastasis of colorectal tumors to the liver by supporting dendritic cell-dependent induction of antitumor CD8+ T cells, which could impact the use of TYK2 inhibitors in patients.
Authors
- Dana Krauß (ORCID: https://orcid.org/0000-0002-7310-4340)
- Martin Holcmann (ORCID: https://orcid.org/0000-0003-3362-1359)
- A. Ebner
- Bernadette Mödl (ORCID: https://orcid.org/0009-0002-9429-315X)
- Irene Scharf
- Mathias Müller (ORCID: https://orcid.org/0000-0002-7879-3552)
- Birgit Strobl (ORCID: https://orcid.org/0000-0001-5716-3212)
- Daniela Zwolanek (ORCID: https://orcid.org/0000-0001-5250-396X)
- Michaela Schlederer
- Maria Sibilia (ORCID: https://orcid.org/0000-0001-6129-5613)
- Emilio Casanova (ORCID: https://orcid.org/0000-0001-7992-5361)
- Robert Eferl (ORCID: https://orcid.org/0000-0002-6074-7144)
- Caroline Lassnig (ORCID: https://orcid.org/0000-0001-7905-3620)
- Lukas Kenner (ORCID: https://orcid.org/0000-0003-2184-1338)
- Dietmar Herndler‐Brandstetter (ORCID: https://orcid.org/0000-0003-0987-0208)
- Philipp Novoszel (ORCID: https://orcid.org/0000-0002-1398-9140)
- Katharina Schwertner (ORCID: https://orcid.org/0000-0002-5916-1058)
- Verónica Moreno‐Viedma (ORCID: https://orcid.org/0000-0003-0906-8725)
- Martina Hammer
- Nunzia Matrone (ORCID: https://orcid.org/0000-0002-1419-2205)
- Cristiano De Sá Fernandes (ORCID: https://orcid.org/0000-0002-2863-8458)
- Stefan Moritsch (ORCID: https://orcid.org/0000-0002-1849-1616)
Institutions
- University of Veterinary Medicine Vienna (AT)
- Comprehensive Cancer Center Vienna (AT)
- Ludwig Boltzmann Institute for Cancer Research (AT)
- Medical University of Vienna (AT)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1158/0008-5472.can-24-4224
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.00