XBP1 expression in pancreatic islet cells is associated with poor glycaemic control especially in young non-obese onset diabetes across ancestries
XBP1 expression is associated with diabetes risk with particular value in under-represented populations at risk of young, non-obese onset diabetes.
Authors
- Daniel G. MacArthur (ORCID: https://orcid.org/0000-0002-5771-2290)
- Ranjit Mohan Anjana (ORCID: https://orcid.org/0000-0002-4843-1374)
- Théo Dupuis (ORCID: https://orcid.org/0000-0002-5057-6222)
- Chris Griffiths (ORCID: https://orcid.org/0000-0001-7935-8694)
- Gerome D. Breen (ORCID: https://orcid.org/0000-0003-2053-1792)
- David Collier (ORCID: https://orcid.org/0000-0003-4087-1559)
- Klaudia Walter (ORCID: https://orcid.org/0000-0003-4448-0301)
- Alison D. McNeilly (ORCID: https://orcid.org/0000-0003-4869-178X)
- Rohini Mathur (ORCID: https://orcid.org/0000-0002-3817-8790)
- Benjamin M. Jacobs (ORCID: https://orcid.org/0000-0002-6023-6010)
- Mohammed Bodrul Mazid
- David A. van Heel (ORCID: https://orcid.org/0000-0002-0637-2265)
- Julia Zöllner (ORCID: https://orcid.org/0000-0002-9072-9131)
- Teng Heng
- Stuart Rison (ORCID: https://orcid.org/0000-0003-3289-6668)
- Kamrul Islam (ORCID: https://orcid.org/0000-0002-5968-7068)
- Vladimir Ovchinnikov (ORCID: https://orcid.org/0000-0003-0350-8478)
- Caroline Winckley
- Margherita Bigossi (ORCID: https://orcid.org/0000-0002-5857-2680)
- Saravanan Jebarani
- Viswanathan Mohan (ORCID: https://orcid.org/0000-0001-5038-6210)
- Michael A. Simpson (ORCID: https://orcid.org/0000-0002-8539-8753)
- Richard C. Trembath (ORCID: https://orcid.org/0000-0003-0550-3400)
- Dan Mason (ORCID: https://orcid.org/0000-0002-0026-9216)
- Sam Hodgson (ORCID: https://orcid.org/0000-0002-5610-850X)
- Caroline E Morton (ORCID: https://orcid.org/0000-0003-0783-0042)
- Ayat Salman (ORCID: https://orcid.org/0000-0002-7747-2757)
- Sabina Yasmin (ORCID: https://orcid.org/0000-0001-8399-1230)
- Shapna Hussain
- Miriam Samuel (ORCID: https://orcid.org/0000-0003-1258-435X)
- Saeed Bidi (ORCID: https://orcid.org/0000-0002-8951-2867)
- Ambra Sartori
- Alasdair Taylor (ORCID: https://orcid.org/0000-0002-4078-217X)
- Sundararajan Srinivasan (ORCID: https://orcid.org/0000-0002-3387-9889)
- Omar Asgar
- Andrew Brown (ORCID: https://orcid.org/0000-0002-8087-3033)
- John Solly
- Fabíola Eto (ORCID: https://orcid.org/0000-0002-0203-8649)
- Claudia Langenberg (ORCID: https://orcid.org/0000-0002-5017-7344)
- Sheik Dowlut
- Adem Y. Dawed (ORCID: https://orcid.org/0000-0003-0224-2428)
- Elizabeth Owor
- Marie Spreckley (ORCID: https://orcid.org/0000-0002-8346-2408)
- Ebenezer Tolu Adedire
- Sarah Finer (ORCID: https://orcid.org/0000-0002-2684-4653)
- Rajendra Pradeepa (ORCID: https://orcid.org/0000-0002-4909-3733)
- Asma Qureshi (ORCID: https://orcid.org/0000-0001-7857-8935)
- Moneeza K. Siddiqui (ORCID: https://orcid.org/0000-0001-9055-3896)
- Daniel Stow (ORCID: https://orcid.org/0000-0002-9534-4521)
- Hilary C. Martin (ORCID: https://orcid.org/0000-0002-4454-9084)
- Joanne E. Harvey (ORCID: https://orcid.org/0000-0001-5687-2586)
- William G. Newman (ORCID: https://orcid.org/0000-0002-6382-4678)
- Shabana Chaudhary
- Matt Hurles
- Ariadna González‐del Angel (ORCID: https://orcid.org/0000-0002-7096-0969)
- Ceri Durham
- Naveed A. Sattar (ORCID: https://orcid.org/0000-0002-1604-2593)
- Nishat Safa
- Grainne Colligan (ORCID: https://orcid.org/0000-0001-7357-2390)
- Panos Deloukas (ORCID: https://orcid.org/0000-0001-9251-070X)
- Joseph Gafton
- Sang Hyuck Lee (ORCID: https://orcid.org/0000-0002-5610-033X)
- Ewan R. Pearson (ORCID: https://orcid.org/0000-0001-9237-8585)
- Iaroslav Popov (ORCID: https://orcid.org/0000-0001-7538-123X)
- James Cantley (ORCID: https://orcid.org/0000-0003-2509-1271)
- Ahsan Khan (ORCID: https://orcid.org/0000-0002-5189-6906)
- Shaheen Akhtar
- Raymond Chung (ORCID: https://orcid.org/0000-0003-0296-5546)
- Samina Ashraf (ORCID: https://orcid.org/0000-0002-3198-7245)
- Eamonn Maher
- Vivek Iyer (ORCID: https://orcid.org/0000-0003-4451-8293)
- Venkatesan Radha (ORCID: https://orcid.org/0000-0002-4281-0250)
- John Wright
- Jessry Russell
- Amna Asif
- Karen Tricker
- Hazera Khatun
- Karen A. Hunt (ORCID: https://orcid.org/0000-0002-2164-6412)
- Jan Whalley
- David Davtian
- Georgios Kalantzis
- Ishevanhu Zengeya
- Emily Mantle
Institutions
- University of Geneva (CH)
- Garvan Institute of Medical Research (AU)
- Queen Mary University of London (GB)
- Aston University (GB)
- University of Dundee (GB)
- King's College London (GB)
- Action for ME (GB)
- London Borough Of Lewisham (GB)
- Wellcome Sanger Institute (GB)
- Ninewells Hospital (GB)
- University of Manchester (GB)
- Madras Diabetes Research Foundation (IN)
- University Hospital of Geneva (CH)
- Dr. Mohan's Diabetes Specialities Centre (IN)
- William Harvey Research Institute (GB)
- Bradford Teaching Hospitals NHS Foundation Trust (GB)
- University of Glasgow (GB)
- Newcastle University (GB)
Publication Details
- Journal
- Communications Medicine
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1038/s43856-025-01076-2
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Bristol-Myers Squibb
- Pfizer
- AstraZeneca
- GlaxoSmithKline
- Alnylam Pharmaceuticals
- University of Dundee
- Wellcome Trust
- NHS Health Scotland
- Scottish Government
- Broad Institute
- Barts Charity
- Maze Therapeutics
- National Institute for Health and Care Research
- Diabetes UK
- Tenovus
- King's College London
- European Commission
- Indian Council of Medical Research
- Novo Nordisk
- Madras Diabetes Research Foundation
- Barts Health NHS Trust
- Medical Research Council