Extracellular Vesicle–Packaged miR-99a Reprograms Fibroblasts to Create an Inflammatory Niche That Drives Colorectal Cancer Metastasis
Extracellular vesicle-mediated cross-talk between colorectal cancer cells and fibroblasts orchestrates a proinflammatory niche that induces and facilitates metastasis and provides potential targets for disease prediction and therapeutic intervention.
Authors
- Mingzhen Zhou
- Yangsong He (ORCID: https://orcid.org/0000-0002-9150-564X)
- Yuanyuan Lu (ORCID: https://orcid.org/0000-0003-0194-8074)
- Hua Han (ORCID: https://orcid.org/0000-0002-1872-9700)
- S. Ji
- Yibo Bian (ORCID: https://orcid.org/0000-0001-6303-6156)
- Xiaodi Zhao (ORCID: https://orcid.org/0000-0002-1817-803X)
- W.‐Z. Liu
- Boda Wang (ORCID: https://orcid.org/0000-0001-5934-4674)
- Stephan Emmrich (ORCID: https://orcid.org/0000-0002-0537-4242)
- Juan Hui (ORCID: https://orcid.org/0000-0002-0791-7669)
- Yi Liu (ORCID: https://orcid.org/0009-0006-3223-1446)
- Hao Liu (ORCID: https://orcid.org/0009-0006-6173-5598)
- Yongzhan Nie (ORCID: https://orcid.org/0000-0003-1124-4548)
- Xin Wang (ORCID: https://orcid.org/0009-0007-0821-8548)
- Yumin Zhao (ORCID: https://orcid.org/0009-0004-3592-6505)
- Qing Chen
- Ge Miao (ORCID: https://orcid.org/0000-0002-4818-3737)
- H.N. Wang
Institutions
- Goethe University Frankfurt (DE)
- Northwest University (CN)
- Tang Du Hospital (CN)
- Xijing Hospital (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1158/0008-5472.can-25-0663
- Citations
- 2
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 1.61