Causal effects of circulating inflammatory proteins on colorectal cancer: a Mendelian randomization and Spatial transcriptomic study
This integrative study provides genetic and spatial evidence supporting the involvement of specific circulating inflammatory proteins in colorectal carcinogenesis. TNFRSF9 and IL20RA may act as pro-tumorigenic mediators, while LAP-TGF-β1 may confer protective effects. These findings offer new insights into inflammation-related CRC pathogenesis and may inform future biomarker or therapeutic targetd evelopment.
Authors
- Bo Wu (ORCID: https://orcid.org/0009-0009-3417-0802)
- Jie Li (ORCID: https://orcid.org/0000-0002-7739-2693)
- Li Zhao (ORCID: https://orcid.org/0000-0001-8015-3055)
- Lingqiong Zhao (ORCID: https://orcid.org/0000-0002-4234-0148)
- Mei Bai (ORCID: https://orcid.org/0000-0002-4037-4176)
Institutions
- Binzhou Medical University (CN)
- Binzhou Technician College (CN)
- Community Health Center (US)
- First People's Hospital of Chongqing (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1007/s12672-025-03656-z
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00