Inhibition of DDR1 potentiates carbon ion radiotherapy by promoting ferroptosis and immunogenic death in head and neck squamous cell carcinoma
Our findings positioned DDR1 targeting as a therapeutic strategy to potentiate CIR through immunogenic ferroptosis induction in HNSCC.
Authors
- Chunlin Shao (ORCID: https://orcid.org/0000-0001-9336-9912)
- Huaiyuan Chen (ORCID: https://orcid.org/0009-0002-9831-7374)
- Lin Kong (ORCID: https://orcid.org/0000-0002-5263-5740)
- Qingting Huang (ORCID: https://orcid.org/0000-0002-9488-5983)
- Xingyu Liu
- Jingqin Zhong (ORCID: https://orcid.org/0000-0003-0332-8688)
- Haojiong Zhang
- Shikai Geng (ORCID: https://orcid.org/0000-0003-2312-0569)
- Fengtao Su (ORCID: https://orcid.org/0000-0003-1836-4606)
- Li Chen (ORCID: https://orcid.org/0000-0003-4464-6383)
- Wei Hu (ORCID: https://orcid.org/0000-0003-3218-664X)
Institutions
- Shanghai University (CN)
- Shanghai Medical College of Fudan University (CN)
- Fudan University Shanghai Cancer Center (CN)
- Shanghai Genon Biological Products (China) (CN)
- Shanghai University of Medicine and Health Sciences (CN)
- Center for High Pressure Science & Technology Advanced Research (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1186/s12967-025-07062-5
- Citations
- 3
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 4.56
Funders
- National Science and Technology Major Project