The Use of Various Materials in the Introduction of Hydrogen Isotopes into Organic Compounds without Solvents

Abstract—Methods of introducing hydrogen isotopes into organic compounds without the use of solvents are described. Inorganic carriers, including nanomaterials, that are used to prepare reaction mixtures are given. The possibilities of a solid-phase method for introducing a deuterium or tritium label into organic compounds, including unsaturated and thermolabile compounds are shown. The influence of reaction conditions on the yield and degree of inclusion of the hydrogen isotope into labeled preparations is considered. An attempt was made to explain the obtained data by the processes that occur in the system hydrogen isotope–catalyst–carrier–nature of the compound.