CCDC137 knockdown suppresses bladder cancer progression by downregulating SCD
This systematic investigation combining multi-omics bioinformatics analyses and experimental validation demonstrates the role of CCDC137 in bladder carcinoma progression, providing novel mechanistic insights into the pathogenesis of BLCA and offering a theoretical foundation for therapeutic targeting of CCDC137 in urothelial malignancies.
Authors
- Hongbing Mei (ORCID: https://orcid.org/0000-0002-6009-4753)
- Wendong Jiang
- Xinhui Liao (ORCID: https://orcid.org/0000-0002-2819-3719)
- Zhiming Cai (ORCID: https://orcid.org/0009-0006-4307-8272)
- Qinghua Mei
- Yuhan Liu (ORCID: https://orcid.org/0000-0003-1990-4184)
- Yuchen Liu (ORCID: https://orcid.org/0000-0002-6517-0022)
- Zhaoyu Li (ORCID: https://orcid.org/0000-0002-5222-6832)
- Bing Yan (ORCID: https://orcid.org/0000-0002-0216-9454)
- Shuanzhu Mou
- Weisheng Huang
- Haiyu Zhang (ORCID: https://orcid.org/0000-0003-3627-7477)
Institutions
- Chinese Academy of Sciences (CN)
- Shantou University (CN)
- Shantou University Medical College (CN)
- Shenzhen University Health Science Center (CN)
- Shenzhen Institutes of Advanced Technology (CN)
- Shenzhen Second People's Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1186/s12967-025-07033-w
- Citations
- 2
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 1.61