Phosphorylation-mimicking histone H3.3 rescues exercise-induced gene responses in an epigenetic aging model of mouse skeletal muscle
Impaired transcriptional responsiveness to exercise in a simulated epigenetic aging model induced by exogenous H3.3 expression was rescued by the phosphorylation-mimicking H3.3S31E variant in middle-aged skeletal muscle. The findings of the present study demonstrate that H3.3S31ph plays a critical role in regulating the stability of H3.3 within chromatin.
Authors
- Fuminori Kawano (ORCID: https://orcid.org/0000-0002-3714-0360)
- S. Maruyama (ORCID: https://orcid.org/0000-0003-0140-5993)
Institutions
- Matsumoto University (JP)
Publication Details
- Journal
- Laboratory Animal Research
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1186/s42826-025-00254-6
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Uehara Memorial Foundation
- Japan Society for the Promotion of Science