Hypoxia reverses the early anti-inflammatory microglial response to the β-amyloid peptide: mitochondrial involvement and beneficial roles of melatonin and naringenin
Our results suggest that mild hypoxic insults during early asymptomatic stages of AD can pose as a risk factor for an accelerated progression of the disease and show the benefits of SIRT1 induction strategies, including use of natural substances like melatonin and naringenin.
Authors
- Andrea Magrì (ORCID: https://orcid.org/0000-0002-7143-7168)
- Stefano Conti Nibali (ORCID: https://orcid.org/0009-0008-0560-378X)
- Sara Merlo (ORCID: https://orcid.org/0000-0002-6558-9800)
- Angela Messina (ORCID: https://orcid.org/0000-0002-5745-9846)
- Aurora Patti
- Cristiana Lucia Rita Lipari
- Maria Angela Sortino
Institutions
- University of Catania (IT)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1186/s12967-025-07044-7
- Citations
- 4
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.66
Funders
- Ministero della Salute
- Università di Catania
- Associazione Italiana Ricerca Alzheimer