Triclabendazole inhibits PKM2 nuclear localization and glycolysis by enhancing HDAC6-mediated deacetylation in lung cancer
Our findings revealed that triclabendazole inhibits PKM2 nuclear localization and glycolysis through an HDAC6-dependent mechanism, leading to the activation of AMPK/mTOR signaling and suppression of lung cancer cell proliferation. These results suggested that triclabendazole holds promise as a potential therapeutic agent, with the HDAC6-PKM2 axis representing a novel target for lung cancer treatment.
Authors
- Jun Fan (ORCID: https://orcid.org/0000-0001-6637-9891)
- Liang Yan (ORCID: https://orcid.org/0000-0002-4479-6819)
- Yong Dai (ORCID: https://orcid.org/0000-0002-6840-9158)
- Qingbing Zha
- Yong Sun (ORCID: https://orcid.org/0000-0003-2324-7180)
- Yifan Zhang (ORCID: https://orcid.org/0000-0003-4890-4490)
- Yuan Li (ORCID: https://orcid.org/0000-0001-9809-9894)
- Lina Qu (ORCID: https://orcid.org/0000-0002-6374-415X)
- Shanshan Shi (ORCID: https://orcid.org/0000-0002-7568-0499)
- Jing Liu (ORCID: https://orcid.org/0009-0008-2772-0418)
Institutions
- Harbin Medical University (CN)
- Jinan University (CN)
- Shanxi Medical University (CN)
- Daqing City People's Hospital (CN)
- Foshan Hospital of TCM (CN)
- Ministry of Education (BN)
- Spinal Research (GB)
- Shanxi Provincial People’s Hospital (CN)
- First Affiliated Hospital of Jinan University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1186/s12967-025-06905-5
- Citations
- 3
- Primary Topic
- Histone Deacetylase Inhibitors Research
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province
- Jinan University