Spatiotemporal microenvironment landscape and malignant epithelial pattern transition in breast ductal carcinoma progression
The stage-specific microenvironmental characteristics of breast ductal carcinoma correspond to some extent to the behavior of tumor cells. During the progression of ductal carcinoma in breast tissue, the establishment of an immunosuppressive microenvironment occurs. The microenvironmental spectrum at lymph node metastases differs somewhat, corresponding to a more enriched turnover of cancer cell proliferation and death. Inhibitors of FAM111B and inducers of cuproptosis and disulfidptosis may serve as potential therapeutic targets for proliferative subgroups.
Authors
- Hengbin Zhang (ORCID: https://orcid.org/0000-0002-6197-5122)
- Bing Yin (ORCID: https://orcid.org/0000-0001-8668-9504)
- Zhuanzhuan Lv (ORCID: https://orcid.org/0000-0002-6375-0381)
- Xifu Cheng (ORCID: https://orcid.org/0009-0009-6262-308X)
- Simin Zhang (ORCID: https://orcid.org/0000-0003-3720-486X)
- Wenjuan Zeng (ORCID: https://orcid.org/0000-0002-5555-5260)
- Yao Zhou (ORCID: https://orcid.org/0000-0002-9680-5246)
- Jiawei Gui (ORCID: https://orcid.org/0009-0006-2007-2425)
Institutions
- Nanchang University (CN)
- Jiangxi Provincial Academy of Medical Sciences (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- Second Affiliated Hospital of Nanchang University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1186/s12967-025-07010-3
- Citations
- 2
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 1.61