IGF-1 downregulates matrix metalloproteinase 8 to promote plaque stability: Evidence from myeloid cell-specific MMP8 in atherosclerosis
IGF-1 downregulated plaque MMP8 levels in control mice, however this effect was markedly blunted in mM8-:M8 + mice showing that macrophages are the main target of IGF-1 downregulation of plaque MMP8. Overall, our results suggest that macrophage MMP8 may be a potential target to treat unstable atherosclerotic plaques.
Authors
- Patricia Snarski (ORCID: https://orcid.org/0000-0002-2470-7655)
- Fareed Sindi
- Vikara Rivera-Lopez
- Patrice Delafontaine (ORCID: https://orcid.org/0000-0003-3744-3617)
- Yusuke Higashi (ORCID: https://orcid.org/0000-0003-1956-0182)
- Tadashi Yoshida (ORCID: https://orcid.org/0000-0002-4544-1497)
- Sergiy Sukhanov (ORCID: https://orcid.org/0000-0002-9223-4263)
- Andrew Gross (ORCID: https://orcid.org/0000-0002-8104-7796)
- Svitlana Danchuk
Institutions
- Tulane University (US)
- Loyola University New Orleans (US)
- University Medical Center New Orleans (US)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1371/journal.pone.0332660
- Primary Topic
- Protease and Inhibitor Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00