Therapeutic Benefit of Upadacitinib in Severe Post-Proctectomy (Class 4) Perianal Crohn’s Disease: A Three-Patient Case Series
This case series describes striking clinical and radiological responses in 3 Crohn's disease patients with persistent perineal complications following proctectomy treated with upadacitinib. It highlights the potential of advanced therapies for this refractory inflammatory bowel disease phenotype with limited treatment options.
Authors
- Serre-Yu Wong (ORCID: https://orcid.org/0000-0002-2070-4123)
- Phillip Lung (ORCID: https://orcid.org/0000-0002-7459-2323)
- T Pelly (ORCID: https://orcid.org/0000-0002-4929-2409)
- Ailsa L Hart (ORCID: https://orcid.org/0000-0002-7141-6076)
- Baseer Quraishi (ORCID: https://orcid.org/0000-0002-0055-7189)
- Nick Powell (ORCID: https://orcid.org/0000-0003-3231-6950)
- Phil Tozer (ORCID: https://orcid.org/0000-0002-2532-7267)
- L Hanna (ORCID: https://orcid.org/0009-0004-8424-202X)
Institutions
- St Mark's Hospital (GB)
- Imperial College London (GB)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Inflammatory Bowel Diseases
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1093/ibd/izaf216
- Primary Topic
- Anorectal Disease Treatments and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00