Gestational trophoblastic neoplasia with pancreatic metastasis: clinical characteristics, treatment strategies, and outcomes
Pancreatic invasion in GTN is a high-risk condition often associated with poor outcomes. Advanced imaging techniques enhance diagnostic accuracy, while endoscopic ultrasound-guided fine-needle biopsy provides essential histopathological confirmation. Multi-agent chemotherapy remains the cornerstone of treatment, with surgical interventions carefully tailored to the individual patient's condition. For better management and prognosis, an initial treatment strategy integrating multi-agent chemotherapy, immunotherapy, and targeted therapies may offer benefits; however, further investigation is warranted.
Authors
- Xinghan Cheng (ORCID: https://orcid.org/0000-0002-4572-9618)
- Jun Zhao (ORCID: https://orcid.org/0000-0002-7658-3842)
- Fengzhi Feng (ORCID: https://orcid.org/0000-0001-9803-9402)
- Dan Wang (ORCID: https://orcid.org/0000-0003-1287-404X)
- Yang Xiang (ORCID: https://orcid.org/0000-0002-9112-1021)
- Xiaoyu Wang (ORCID: https://orcid.org/0000-0002-9075-1769)
- Xiaoyan Chang (ORCID: https://orcid.org/0000-0002-0732-6551)
- Yang Gui
- Junjun Yang (ORCID: https://orcid.org/0000-0002-5625-0119)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
Publication Details
- Journal
- Orphanet Journal of Rare Diseases
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1186/s13023-025-04014-6
- Citations
- 1
- Primary Topic
- Gestational Trophoblastic Disease Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.88
Funders
- National Natural Science Foundation of China
- Peking Union Medical College Hospital
- National Key Research and Development Program of China