PlyNJ3: a three-domain endolysin with broad-spectrum anti-streptococcal activity and synergistic efficacy against multidrug-resistant Streptococcus suis
Our findings establish SMphage-derived lysins as a conserved, therapeutically valuable class of antimicrobials with inherent broad-spectrum potential across diverse streptococcal pathogens. Building on the previously demonstrated in vivo efficacy of PlySK1249 against S. dysgalactiae and S. agalactiae, we show that its structural homolog, PlyNJ3, exhibits robust therapeutic activity against S. suis infections. Together, these results validate the SMphage lysin platform for generating precision-targeted agents against specific streptococcal infections.
Authors
- Hui Ji (ORCID: https://orcid.org/0000-0002-1674-6056)
- Jinhu Huang (ORCID: https://orcid.org/0000-0001-8149-1486)
- Xiaoming Wang (ORCID: https://orcid.org/0000-0003-4559-7413)
- Shanqiang Gu (ORCID: https://orcid.org/0000-0002-9292-9129)
- Peizhao Han
- Jiaqi Zhao
- J. Wang
- Cai Yin
- Liping Wang (ORCID: https://orcid.org/0000-0002-1225-1427)
Institutions
- Nanjing Agricultural University (CN)
- Animal Husbandry and Veterinary Department (IN)
- Ningxia Center for Diseases Prevention and Control (CN)
Publication Details
- Journal
- BMC Veterinary Research
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1186/s12917-025-04975-7
- Citations
- 1
- Primary Topic
- Streptococcal Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.88
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Ningxia Province
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- Fundamental Research Funds for the Central Universities