Clinical characteristics and outcomes of COVID-19-Associated acute encephalopathy in pediatric patients during the Omicron wave in beijing: a single-center prospective study
Omicron-associated AE in young children is characterized by rapidly progressive neurological deterioration, with 60% mortality in this cohort and persistent deficits in survivors. Symmetric MRI lesions, elevated procalcitonin, and CSF cytokine elevation may serve as early diagnostic indicators. Vaccination gaps and innate immune dysregulation likely contribute to severe outcomes.
Authors
- Siyuan Huang (ORCID: https://orcid.org/0000-0001-8179-4057)
- Wei Li (ORCID: https://orcid.org/0000-0002-0248-5510)
- Shuang Liu (ORCID: https://orcid.org/0000-0001-9184-0782)
- Ning Li (ORCID: https://orcid.org/0009-0001-3714-5524)
- Fang Li (ORCID: https://orcid.org/0000-0002-2188-3397)
- Jing Chen (ORCID: https://orcid.org/0000-0003-0429-6518)
- YuChun Yan
- Dong Qu
Institutions
- Capital Medical University (CN)
- Capital Institute of Pediatrics (CN)
- Beijing Children’s Hospital (CN)
- Beijing Chaoyang Emergency Medical Center (CN)
Publication Details
- Journal
- BMC Pediatrics
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1186/s12887-025-05970-5
- Primary Topic
- Infectious Encephalopathies and Encephalitis
- Type
- article
- Field-Weighted Citation Impact
- 0.00