Longitudinal Evaluation of Circulating Tumor DNA as a Prognostic Biomarker to Detect Molecular Residual Disease in Germ Cell Tumors
Tumor-informed ctDNA analysis shows promise for MRD detection in patients with GCTs. With further study, ctDNA monitoring may be useful in clinical decision making. Larger prospective trials are planned to establish clinical utility.
Authors
- Adam Rock (ORCID: https://orcid.org/0000-0002-5859-6965)
- Reuben Ben‐David (ORCID: https://orcid.org/0000-0001-7946-7145)
- Rebecca Hassoun (ORCID: https://orcid.org/0000-0001-8997-890X)
- Neeraja Tillu (ORCID: https://orcid.org/0000-0002-4149-0486)
- Cherry Au (ORCID: https://orcid.org/0000-0002-8483-0647)
- John P. Sfakianos (ORCID: https://orcid.org/0000-0002-3101-0266)
- Kevin Manage (ORCID: https://orcid.org/0000-0003-1992-0782)
- Timothy A. Masterson (ORCID: https://orcid.org/0000-0001-7354-1359)
- Clint Cary
- Shruti Sharma
- Minetta C. Liu (ORCID: https://orcid.org/0000-0002-8206-5232)
- Punashi Dutta (ORCID: https://orcid.org/0000-0002-0166-498X)
- George Laliotis (ORCID: https://orcid.org/0000-0001-9205-8258)
- Jennifer King (ORCID: https://orcid.org/0000-0003-3413-451X)
- Adam C. ElNaggar (ORCID: https://orcid.org/0000-0003-3409-583X)
- Alex Chehrazi‐Raffle (ORCID: https://orcid.org/0000-0001-5205-4527)
- Lawrence H. Einhorn (ORCID: https://orcid.org/0000-0001-7971-7669)
- Nabil Adra (ORCID: https://orcid.org/0000-0001-8905-8329)
- Jordan Rich (ORCID: https://orcid.org/0000-0002-4434-5321)
- Shivaram Cumarasamy
- Tanya Barauskas Dorff (ORCID: https://orcid.org/0000-0001-5990-298X)
- Alan Tan (ORCID: https://orcid.org/0000-0002-6350-5917)
- Mukti Patel
Institutions
- Indiana University Health (US)
- Rush University Medical Center (US)
- City of Hope (US)
- Natera (United States) (US)
- Indiana University Melvin and Bren Simon Comprehensive Cancer Center
- Indiana University – Purdue University Indianapolis (US)
- Vanderbilt University Medical Center (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- JCO Precision Oncology
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1200/po-25-00176
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00