Association between LRRK2 gene polymorphisms and Parkinson’s disease progression in a Chinese Han population
Our findings suggest that <i>LRRK2</i> rs34778348 and rs7304279 polymorphisms are associated with the risk of developing PD. And <i>LRRK2</i> rs7304279 polymorphism is correlated with disease progression in PD patients.
Authors
- Ruifang She
- Zhonglin Ge
- Bing Fu (ORCID: https://orcid.org/0000-0002-5861-5708)
- Jianhua Liu (ORCID: https://orcid.org/0009-0006-4821-3189)
- Weiguo Liu (ORCID: https://orcid.org/0000-0001-5916-9837)
- Qianqian He
- Jian Gao (ORCID: https://orcid.org/0000-0001-7636-911X)
- Zhaoting Zhang (ORCID: https://orcid.org/0000-0001-9760-1125)
- Lei Geng (ORCID: https://orcid.org/0000-0003-3471-1890)
Institutions
- Nanjing Brain Hospital (CN)
- The First People’s Hospital of Lianyungang (CN)
- Xian Yang Central Hospital (CN)
- Taian City Central Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2025-09-24
- DOI
- https://doi.org/10.3389/fgene.2025.1662348
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province