Structural Change of Neurotransmitter Amine with CO<sub>2</sub> in Water: Formation of Covalently Bound Carbamic Acid
Structural transformation changes the activity of biological reactions. Neurotransmitter aralkylamines, such as phenethylamine, tyramine, dopamine, tryptamine, serotonin, and histamine, absorb aerial CO<sub>2</sub>, and heteronuclear multiple bond connectivity (HMBC) correlations between the carbon derived from CO<sub>2</sub> and the α-hydrogen of the several amines were confirmed in the D<sub>2</sub>O solution. The isolation of methyl carbamate from phenethylamine and CO<sub>2</sub> in water with TMSCHN<sub>2</sub> also supported the formation of covalently bound carbamic acid in the amine aqueous solution containing CO<sub>2</sub>. Therefore, it is suggested that CO<sub>2</sub> produced in the body would react with neurotransmitter amines to form covalently bound carbamic acid, which might affect biological reactions.
Authors
- Ryo Murakami (ORCID: https://orcid.org/0000-0003-0445-3368)
- Fuyuhiko Inagaki (ORCID: https://orcid.org/0000-0003-2999-083X)
- Keitaro Shiota (ORCID: https://orcid.org/0009-0003-7760-6086)
Institutions
- Kobe Gakuin University (JP)
Publication Details
- Journal
- Chemical and Pharmaceutical Bulletin
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1248/cpb.c25-00463
- Primary Topic
- Chemical Reactions and Isotopes
- Type
- article
- Field-Weighted Citation Impact
- 0.00