MK2-mediated AKT/MYC signaling activation promotes epithelial-mesenchymal transition in lung adenocarcinoma
Our findings suggest that MK2 promotes migration and invasion in LUAD through the AKT/MYC signaling pathways, positioning MK2 as a potential therapeutic target in LUAD treatment.
Authors
- Rong Qi (ORCID: https://orcid.org/0000-0002-0627-9968)
- Penghui Liu (ORCID: https://orcid.org/0000-0002-9078-6638)
- Guohua Zhang (ORCID: https://orcid.org/0000-0001-6713-9304)
- Feng Qiu (ORCID: https://orcid.org/0000-0002-3654-0565)
- Chao Shi (ORCID: https://orcid.org/0000-0003-2347-6127)
- Fang Chen (ORCID: https://orcid.org/0000-0003-4196-9734)
- Weiguo Gu
Institutions
- Nanchang University (CN)
- First Affiliated Hospital of Nanchang University (CN)
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2025-09-24
- DOI
- https://doi.org/10.3389/fgene.2025.1615018
- Primary Topic
- Cancer Mechanisms and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Jiangxi Province