Enhancement of lentiviral vectors gene delivery against VEGFR2 expressing cells by co-display of the binding and fusogenic moieties: a two molecules targeting approach
Compared to the chimeric strategy, the two-molecule targeting approach of LVs, due to its flexible and modular nature provides higher TE and thus great potentials for targeted gene delivery.
Authors
- Farzin Roohvand (ORCID: https://orcid.org/0000-0002-9597-3555)
- Reza Ahangari Cohan (ORCID: https://orcid.org/0000-0002-0490-4184)
- Nasir Mohajel (ORCID: https://orcid.org/0000-0001-8883-4429)
- Mohammad Hossein Etemadzadeh
- Mohamad Reza Kalani (ORCID: https://orcid.org/0000-0002-8756-1200)
- Navid Madani (ORCID: https://orcid.org/0000-0002-6679-6078)
- Mahdi Behdani (ORCID: https://orcid.org/0000-0002-4839-5123)
- Kayhan Azadmanesh (ORCID: https://orcid.org/0000-0002-7165-9043)
- Roshanak Ahani
Institutions
- Pasteur Institute of Iran (IR)
- Biotechnology Research Center (IR)
- Dana-Farber Cancer Institute (US)
- University of Pittsburgh Medical Center (US)
Publication Details
- Journal
- Virology Journal
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1186/s12985-025-02923-3
- Primary Topic
- Virus-based gene therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Pasteur Institute of Iran