ALYREF inhibits ferroptosis in vascular endothelial cells and improves atherosclerosis by epigenetic modification of CISD1
By enhancing m<sup>5</sup>C modification, ALYREF enhances the stability and expression of CISD1 mRNA, which impedes lipid metabolism and endothelial cell ferroptosis in AS and alleviates AS-associated pathological changes.
Authors
- Wenjun Xiong (ORCID: https://orcid.org/0000-0002-2967-6245)
- Minzi Qiu
- Ling Yu (ORCID: https://orcid.org/0000-0001-6395-6630)
- Jianbing Zhu (ORCID: https://orcid.org/0000-0001-8186-9549)
- Qiong Duan (ORCID: https://orcid.org/0000-0002-2957-5129)
- Xiaoping Peng (ORCID: https://orcid.org/0000-0002-0401-7331)
- Ru Ying (ORCID: https://orcid.org/0000-0001-6443-3903)
- Jinghai Hua
Institutions
- Nanchang University (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- Second Affiliated Hospital of Nanchang University (CN)
- Jiangxi Transportation Research Institute (CN)
- First Affiliated Hospital of Nanchang University (CN)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1186/s13148-025-01955-4
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00