USP28 participates in high glucose-mediated endothelial dysfunction via deubiquitinating SIRT1 protein in diabetic foot ulcers
USP28 weakens HG-mediated endothelial dysfunction via activating the NRF2/HO-1 pathway through stabilizing SIRT1 protein, indicating that targeting USP28 is the direction for developing clinical strategies for diabetic wound healing.
Authors
- Jinsong Bai (ORCID: https://orcid.org/0000-0002-2557-0785)
- Kuanzhi Liu
- Qiong Liu (ORCID: https://orcid.org/0000-0002-6431-3650)
- Jin Zhang (ORCID: https://orcid.org/0000-0001-6925-9246)
Institutions
- Hebei Medical University (CN)
- Third Hospital of Hebei Medical University (CN)
- First Hospital of Shijiazhuang (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1186/s13018-025-06244-7
- Citations
- 1
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 1.35