Alteration of the follicular fluid amino acid profile reveals the important roles of several amino acids in embryo quality in patients with polycystic ovary syndrome
Our research has the potential to provide valuable insights regarding the involvement of amino acid abnormalities in follicular fluid in the pathophysiology of PCOS. The findings indicated the possibility of variations in amino acid composition, and consequently variations in embryo quality, among normal and PCOS women. Additional research is required in order to substantiate these findings and directly assess the effects on pregnancy and live birth outcomes.
Authors
- Wei Cai (ORCID: https://orcid.org/0000-0001-9324-5987)
- Wei Guo (ORCID: https://orcid.org/0000-0001-6189-0543)
- Yongning Lu (ORCID: https://orcid.org/0000-0001-7172-9913)
- Beili Wang (ORCID: https://orcid.org/0000-0001-5167-170X)
- Xuan Zhang (ORCID: https://orcid.org/0000-0001-9967-2103)
- Qi Che
- Xi Dong (ORCID: https://orcid.org/0000-0002-3903-0747)
- Yu Li (ORCID: https://orcid.org/0000-0001-8375-709X)
- Miao Liu (ORCID: https://orcid.org/0000-0003-0912-5101)
- Shuo Li (ORCID: https://orcid.org/0000-0003-2686-4934)
- Minna Shen
- Dan Shen
- Suying Liu (ORCID: https://orcid.org/0000-0002-3148-2247)
- Xiaowei Ji (ORCID: https://orcid.org/0000-0002-7569-2799)
- Baishen Pan
- Chen Wang (ORCID: https://orcid.org/0009-0004-4302-2565)
Institutions
- Shanghai Medical College of Fudan University (CN)
- Sun Yat-sen University (CN)
- Fudan University (CN)
- Zhongshan Hospital of Xiamen University (CN)
- Zhongshan Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Dian Diagnostics (China) (CN)
Publication Details
- Journal
- Reproductive Biology and Endocrinology
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1186/s12958-025-01460-6
- Citations
- 1
- Primary Topic
- Ovarian function and disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.70
Funders
- National Natural Science Foundation of China
- Fudan University