FTO regulates testosterone secretion in Leydig cells: insights into the role of m6A modifications and the therapeutic potential of hCG
Our study provides new evidence that FTO plays a critical role in regulating testosterone secretion in LCs. Additionally, we demonstrate that hCG treatment can restore testosterone production impaired by FTO inhibition. These findings offer valuable insights into the molecular mechanisms underlying testosterone secretion and may inform therapeutic strategies for male infertility and hypogonadism.
Authors
- Fang Gao (ORCID: https://orcid.org/0000-0001-5769-454X)
- Kebing Yang
- Xianhua Fu (ORCID: https://orcid.org/0000-0003-1676-5932)
- Chenglu Wang
- Zheng Min
Institutions
- Hangzhou Medical College (CN)
Publication Details
- Journal
- Reproductive Biology and Endocrinology
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1186/s12958-025-01456-2
- Citations
- 1
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Medical Science and Technology Project of Zhejiang Province
- Science and Technology Program of Zhejiang Province