Infectious Mimics of Bell's Palsy: Facial Nerve Palsy Due to Lyme Neuroborreliosis

Facial nerve palsy (FNP) is a common neurological disorder. There are multiple causes of FNP, and Bell's palsy is defined as an idiopathic cause of FNP. If a patient presents with facial palsy, a full investigation workup should be performed. Lyme disease can present with erythema migrans, fever, headache, muscle and joint pain, and facial palsy. We present a case of a 47-year-old man who presented with progression from unilateral to bilateral FNP. After a series of investigations, he was diagnosed with LNB. Even if MRI findings are normal, cerebrospinal fluid (CSF) analysis and Lyme serology (enzyme-linked immunosorbent assay followed by Western blot) in serum and/or CSF can confirm the diagnosis of neuroborreliosis. We have administered the patient IV ceftriaxone 2 g daily, as per the guidelines. He showed gradual improvement in FNP from House-Brackmann Grade V to Grade II on subsequent follow-ups. This case emphasizes the importance of broad clinical evaluation in diagnosing FNP. Early detection of LNB and initiation of treatment can ensure patients have a favorable outcome.

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Journal
Cureus
Published
2025-09-24
DOI
https://doi.org/10.7759/cureus.93122
Primary Topic
Facial Nerve Paralysis Treatment and Research
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article
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article

Infectious Mimics of Bell's Palsy: Facial Nerve Palsy Due to Lyme Neuroborreliosis

Aung Oo, Tha Mon, Aye Nyein
Cureus
Facial Nerve Paralysis Treatment and Research
article

Infectious Mimics of Bell's Palsy: Facial Nerve Palsy Due to Lyme Neuroborreliosis

Aung Oo, Tha Mon, Aye Nyein
article en

Abstract

Facial nerve palsy (FNP) is a common neurological disorder. There are multiple causes of FNP, and Bell's palsy is defined as an idiopathic cause of FNP. If a patient presents with facial palsy, a full investigation workup should be performed. Lyme disease can present with erythema migrans, fever, headache, muscle and joint pain, and facial palsy. We present a case of a 47-year-old man who presented with progression from unilateral to bilateral FNP. After a series of investigations, he was diagnosed with LNB. Even if MRI findings are normal, cerebrospinal fluid (CSF) analysis and Lyme serology (enzyme-linked immunosorbent assay followed by Western blot) in serum and/or CSF can confirm the diagnosis of neuroborreliosis. We have administered the patient IV ceftriaxone 2 g daily, as per the guidelines. He showed gradual improvement in FNP from House-Brackmann Grade V to Grade II on subsequent follow-ups. This case emphasizes the importance of broad clinical evaluation in diagnosing FNP. Early detection of LNB and initiation of treatment can ensure patients have a favorable outcome.

CureusVol. 17(9)
University of Alabama at Birmingham Hospital (US), University of Liverpool (GB), Blackpool Victoria Hospital (GB), Blackpool Teaching Hospitals NHS Foundation Trust (GB), NIHR Surgical Reconstruction and Microbiology Research Centre (GB)
Openalex Percentile: Top 63%
Facial Nerve Paralysis Treatment and Research
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