Zilebesiran Add-On Treatment for Inadequately Controlled Hypertension

To the Editor We have 2 concerns about a recent clinical trial1 evaluating the efficacy and safety of subcutaneous zilebesiran combined with first-line oral antihypertensives for continuous blood pressure control.

Authors

Zhaohua Zhu (ORCID: https://orcid.org/0000-0003-3913-2564)
Tianyu Chen (ORCID: https://orcid.org/0000-0002-4211-5581)

Institutions

UNSW Sydney (AU)
The George Institute for Global Health (AU)
Zhujiang Hospital (CN)
Southern Medical University (CN)

Publication Details

Journal: JAMA
Published: 2025-09-24
DOI: https://doi.org/10.1001/jama.2025.13326
Primary Topic: Blood Pressure and Hypertension Studies
Type: article
Field-Weighted Citation Impact: 0.00

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article

Zilebesiran Add-On Treatment for Inadequately Controlled Hypertension

Zhaohua Zhu, Tianyu Chen

Sep 24, 2025

JAMA

Blood Pressure and Hypertension Studies

article

Zilebesiran Add-On Treatment for Inadequately Controlled Hypertension

Zhaohua Zhu, Tianyu Chen

September 24, 2025article en

Abstract

JAMAVol. 334(17)

UNSW Sydney (AU), The George Institute for Global Health (AU), Zhujiang Hospital (CN), Southern Medical University (CN)

Openalex Percentile: Top 60%

Blood Pressure and Hypertension Studies

DOI Source OpenAlex

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Zilebesiran Add-On Treatment for Inadequately Controlled Hypertension — Zhaohua Zhu, Tianyu Chen · JAMA (2025) | TGRS Research Map | TGRS