Atenolol rescues premature mortality in genetic mouse models of sudden unexpected death in epilepsy
The data support the premise that LOF KCNH2 variants can contribute to SUDEP risk in a subset of epilepsy patients. Our findings also highlight the potential use of β-blockers as a prevention strategy in SUDEP.
Authors
- Alibek Kuanyshbek (ORCID: https://orcid.org/0000-0002-4886-2115)
- Lauren E. Bleakley (ORCID: https://orcid.org/0000-0001-5611-6860)
- Christopher Semsarian (ORCID: https://orcid.org/0000-0001-6441-274X)
- Erlina S. Mohamed Syazwan
- Ming S. Soh (ORCID: https://orcid.org/0000-0002-5689-2082)
- Chaseley E. McKenzie (ORCID: https://orcid.org/0000-0001-9022-5702)
- A. Marie Phillips (ORCID: https://orcid.org/0000-0002-3638-2077)
- Ingrid Eileen Scheffer (ORCID: https://orcid.org/0000-0002-2311-2174)
- Hian M. Lee
- Samuel F. Berkovic (ORCID: https://orcid.org/0000-0003-4580-841X)
- Amanda Hu (ORCID: https://orcid.org/0000-0002-1292-1582)
- Christopher A. Reid (ORCID: https://orcid.org/0000-0002-1457-8028)
Institutions
- The University of Sydney (AU)
- Royal Children's Hospital (AU)
- The University of Melbourne (AU)
- Florey Institute of Neuroscience and Mental Health (AU)
- Royal Prince Alfred Hospital (AU)
- Centenary Institute (AU)
- Murdoch Children's Research Institute (AU)
- Austin Health (AU)
Publication Details
- Journal
- Epilepsia
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1111/epi.18642
- Citations
- 1
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 1.39