CRB2 Activates an Epigenetic Axis to Promote Ferroptosis in Head and Neck Squamous Cell Carcinoma
CRB2 epigenetically inhibits SCL7A11-GPX4 signaling to promote ferroptosis and suppress tumor growth in head and neck squamous cell carcinoma, providing insights that could guide ferroptosis-activating treatment approaches.
Authors
- Shanhong Lu (ORCID: https://orcid.org/0000-0002-2148-3537)
- Junli Hu (ORCID: https://orcid.org/0000-0003-1946-8714)
- Helei Yan (ORCID: https://orcid.org/0000-0001-5552-503X)
- Gangcai Zhu (ORCID: https://orcid.org/0000-0002-7347-3816)
- Zhongkuo Yu
- Huihong Chen (ORCID: https://orcid.org/0009-0009-5295-4918)
- Junwei Hou (ORCID: https://orcid.org/0000-0001-6588-9785)
- Guo Li (ORCID: https://orcid.org/0000-0001-7646-4213)
- Diekuo Zhang (ORCID: https://orcid.org/0000-0002-7449-1872)
- Mien‐Chie Hung (ORCID: https://orcid.org/0000-0003-4317-4740)
- Xin Zhang (ORCID: https://orcid.org/0000-0002-9273-6212)
- Chao Liu
- Yong Liu (ORCID: https://orcid.org/0000-0001-5102-0309)
- Yuanzheng Qiu
- Zhaoyi Lu (ORCID: https://orcid.org/0000-0002-8567-2513)
- Y. Ding (ORCID: https://orcid.org/0009-0002-5429-9995)
Institutions
- Central South University (CN)
- Johns Hopkins University (US)
- China Medical University (TW)
- Hunan Mawangdui Hospital (CN)
- National Clinical Research (US)
- Education Department of Hunan Province (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1158/0008-5472.can-24-3866
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00