Evaluating the Optic Nerve Crush Model to Understand the Function of Microglia in Glaucoma Neuroprotection
Microglial activation is secondary to axonal injury and plays a bystander role in the ONC model. Robust RGC and axonal degeneration appear unaffected by activated microglia. This finding challenges the utility of the ONC model for evaluating microglia-based glaucoma treatments. Additionally, the study reaffirms the value of combining fluorescent reporter mouse lines with noninvasive ocular imaging for streamlining future research.
Authors
- Jeffrey Eastham (ORCID: https://orcid.org/0000-0002-0612-363X)
- Gyeong Jin Kang (ORCID: https://orcid.org/0000-0002-5824-8012)
- Miriam Baca (ORCID: https://orcid.org/0000-0001-8620-8440)
- Xiaowu Gu (ORCID: https://orcid.org/0000-0003-2266-5516)
- Jar-Fee Yung
- Marion Jeanne (ORCID: https://orcid.org/0000-0001-7334-3061)
- Jeffrey W. Hofmann
- Tiffany Heaster-Ford
- Tae‐Hoon Kim (ORCID: https://orcid.org/0000-0002-2552-0665)
- Tom Truong
- S. Chaney (ORCID: https://orcid.org/0000-0002-0227-7500)
Institutions
- Kaiser Permanente South San Francisco Medical Center (US)
- Eos Neuroscience (United States) (US)
- Sunesis (United States) (US)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1167/iovs.66.12.56
- Citations
- 2
- Primary Topic
- Glaucoma and retinal disorders
- Type
- article
- Field-Weighted Citation Impact
- 3.41
Funders
- Genentech