Anal cancer incidence among women with a history of vulvar cancer by histology, age, and time since diagnosis

Women with a history of vulvar cancer face a high risk of anal cancer; however, incidence according to histology, age-at, and time since vulvar cancer diagnosis remains unexplored. Using data from SEER-8 and SEER-17 registries, we identified 21,230 women with vulvar cancer, with 154,825 person-years follow-up from 1975 to 2021. We observed 95 anal cancer cases, resulting in an incidence of 61.4 per 100,000 person-years (95% CI, 49.6-75.0). Incidence was higher among women with vulvar squamous cell carcinoma (SCC) (78.7; 95% CI, 62.9-97.1) than vulvar non-SCC (19.8; 95% CI, 9.0-37.6). The highest incidence (>100 per 100,000) was observed in women <45 years old with vulvar SCC and those >10 years post-diagnosis. These findings could inform anal cancer screening guidelines, as women with vulvar cancer, particularly those diagnosed with SCC, may substantially benefit from heightened surveillance or targeted screening.

Authors

Institutions

Publication Details

Journal
The Oncologist
Published
2025-09-24
DOI
https://doi.org/10.1093/oncolo/oyaf307
Primary Topic
Colorectal and Anal Carcinomas
Type
article
Field-Weighted Citation Impact
0.00

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Anal cancer incidence among women with a history of vulvar cancer by histology, age, and time since diagnosis

Haluk Damgacioglu, Ashish A. Deshmukh, Keith Magnus Sigel, Brian Orr et al.
The Oncologist
Colorectal and Anal Carcinomas
article

Anal cancer incidence among women with a history of vulvar cancer by histology, age, and time since diagnosis

Haluk Damgacioglu, Ashish A. Deshmukh, Keith Magnus Sigel, Brian Orr, Elizabeth Y. Chiao, Gweneth B. Lazenby, Kalyani Sonawane, Gary M. Clifford, Jane R. Montealegre, Joel M. Palefsky
article en

Abstract

Women with a history of vulvar cancer face a high risk of anal cancer; however, incidence according to histology, age-at, and time since vulvar cancer diagnosis remains unexplored. Using data from SEER-8 and SEER-17 registries, we identified 21,230 women with vulvar cancer, with 154,825 person-years follow-up from 1975 to 2021. We observed 95 anal cancer cases, resulting in an incidence of 61.4 per 100,000 person-years (95% CI, 49.6-75.0). Incidence was higher among women with vulvar squamous cell carcinoma (SCC) (78.7; 95% CI, 62.9-97.1) than vulvar non-SCC (19.8; 95% CI, 9.0-37.6). The highest incidence (>100 per 100,000) was observed in women <45 years old with vulvar SCC and those >10 years post-diagnosis. These findings could inform anal cancer screening guidelines, as women with vulvar cancer, particularly those diagnosed with SCC, may substantially benefit from heightened surveillance or targeted screening.

The OncologistVol. 30(10)
The University of Texas MD Anderson Cancer Center (US), Medical University of South Carolina (US), University of California, San Francisco (US), MUSC Hollings Cancer Center (US), Centre international de recherche sur le cancer (FR), University of San Francisco (US), Icahn School of Medicine at Mount Sinai (US)
World Health Organization, National Cancer Institute
Openalex Percentile: Top 59%
Colorectal and Anal Carcinomas
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.