The Constituent Analysis and the Anti-diabetic Activity of Cyclocarya paliurus (Batal) Iljinsk

Introduction: Cyclocarya paliurus (Batal) Iljinsk, a traditional Chinese medicinal herb, has been historically used for diabetes management. This study aimed to identify some key bioactive compounds in C. paliurus and evaluate their anti-diabetic effects. Methods: The bioactive compounds in C. paliurus were identified and structurally characterized using HPLC-ESI-HRMS fragmentation analysis. The anti-diabetic activity of the ethyl acetate and n-butanol extracts was subsequently evaluated through both in vitro and in vivo experiments. Results: Constituent analysis successfully identified some key bioactive compounds in C. paliurus. In vitro and in vivo bioactivity experiments demonstrated that both two extracts exerted moderate effects of glucose utilization improvement. Conclusion: The findings suggest that C. paliurus extracts contain bioactive compounds capable of improving glucose metabolism in insulin-resistant conditions. The observed in vitro and in vivo anti-diabetic effects support its traditional application in diabetes management. conclusion: This study highlights the therapeutic potential of C. paliurus extracts in alleviating insulin resistance and type II diabetes, providing a scientific basis for its application in functional foods or herbal medicines.