Stratifying atherosclerotic cardiovascular disease by SMuRF burden in a Middle-Eastern country: A multiregistry study of demographics, comorbidities, and therapeutic trends
This study provides valuable insight into the clinical characteristics and management patterns of Middle Eastern patients with atherosclerotic cardiovascular disease (ASCVD), stratified according to the burden of standard modifiable risk factors (SMuRFs). An increased SMuRF burden was associated with a higher prevalence of comorbid conditions, including hypertension, diabetes mellitus, dyslipidemia, chronic kidney disease, and heart failure. Utilizing data from six regional registries, this study represents the first comprehensive, region-specific analysis of the role of modifiable risk factors in this population. The findings underscore the critical need for individualized, risk-based prevention and management strategies to mitigate the rising burden of ASCVD across the Middle East.
Authors
- Alanoud Alobaidly (ORCID: https://orcid.org/0000-0001-9126-237X)
- Haitham Khatatbeh (ORCID: https://orcid.org/0000-0003-2019-6621)
- Ahmad Rajeh Saifan (ORCID: https://orcid.org/0000-0003-1762-4445)
- Anas Ababneh (ORCID: https://orcid.org/0000-0001-8044-3554)
- Zainab Albikawi (ORCID: https://orcid.org/0000-0002-9587-5242)
- Mohamad Jarrah (ORCID: https://orcid.org/0000-0003-4218-7128)
- Fadwa Alhalaiqa (ORCID: https://orcid.org/0000-0002-0899-7883)
- Abdulhafith Alharbi (ORCID: https://orcid.org/0000-0003-3490-3315)
- Abdullah Al Hasan
- Nader Alotaibi
- Osama Alkouri (ORCID: https://orcid.org/0000-0002-3170-6714)
- Nezam Al-Nsair (ORCID: https://orcid.org/0000-0002-6947-2642)
- Mohannad Eid AbuRuz (ORCID: https://orcid.org/0000-0002-2773-4405)
- Mohammad Hamdi Abuadas (ORCID: https://orcid.org/0000-0002-2739-7314)
- Ayman Jaber Hammoudeh (ORCID: https://orcid.org/0000-0003-4940-2679)
- Omar Qaladi (ORCID: https://orcid.org/0000-0002-8681-1562)
Institutions
- Public Authority for Applied Education and Training (KW)
- Jordan University of Science and Technology (JO)
- Flinders University (AU)
- Jordan Hospital (JO)
- King Saud University (SA)
- University of Ha'il (SA)
- Mohammed Bin Rashid University of Medicine and Health Sciences (AE)
- Qatar University (QA)
- Yarmouk University (JO)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-09-22
- DOI
- https://doi.org/10.1371/journal.pone.0332302
- Citations
- 1
- Primary Topic
- Lipoproteins and Cardiovascular Health
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- Mohammed Bin Rashid University of Medicine and Health Sciences