FXR splicing by SF3B3 promotes MYC-driven hepatocarcinogenesis
SF3B3 is a key downstream effector of MYC -driven hepatocarcinogenesis and a critical regulator of FXR splicing. Both SF3B3 and FXR represent druggable vulnerabilities in MYC -amplified HCC.
Authors
- Haichuan Wang (ORCID: https://orcid.org/0000-0002-6886-5698)
- Jiahua Luo (ORCID: https://orcid.org/0000-0002-7911-5841)
- Xichuan Li (ORCID: https://orcid.org/0000-0002-0863-5479)
- Lifeng Han (ORCID: https://orcid.org/0000-0002-9464-2850)
- Gen Li (ORCID: https://orcid.org/0000-0003-0087-7796)
- Weihua Zhang (ORCID: https://orcid.org/0000-0002-4165-5260)
- Xue Chao Wang (ORCID: https://orcid.org/0000-0002-2381-9145)
- Ming Zhang (ORCID: https://orcid.org/0000-0002-6027-4594)
- Tong Xu (ORCID: https://orcid.org/0000-0001-9946-5956)
- Youcai Zhang (ORCID: https://orcid.org/0000-0001-9919-6442)
Institutions
- Tianjin University of Traditional Chinese Medicine (CN)
- Tianjin Normal University (CN)
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Cancer Center of Hawaii (US)
- Tianjin haihe hospital (CN)
Publication Details
- Journal
- Hepatology
- Published
- 2025-09-23
- DOI
- https://doi.org/10.1097/hep.0000000000001523
- Citations
- 1
- Primary Topic
- RNA and protein synthesis mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.81