Quantitative analysis of human adult pancreatic histology reveals separate fatty and fibrotic phenotypes in type 2 diabetes
Systematic human pancreatic analysis revealed two separate type 2 diabetes phenotypes: fatty, associated with central obesity; and fibrotic, associated with reduced beta cell mass without central obesity. This suggests distinct underlying pathogenic mechanisms and has potential for developing personalised disease-modifying therapeutics.
Authors
- Christine S. Flaxman (ORCID: https://orcid.org/0009-0002-1144-7767)
- Nicole Kattner (ORCID: https://orcid.org/0000-0002-2930-5719)
- Charlotte Brack
- Nicola Dyson (ORCID: https://orcid.org/0000-0002-4173-1913)
- Rowen Coulthard
- Yara Al-Selwi
- Sarah J. Richardson (ORCID: https://orcid.org/0000-0002-1160-6062)
- James Shaw (ORCID: https://orcid.org/0000-0002-2893-3211)
- Minna Honkanen‐Scott (ORCID: https://orcid.org/0000-0002-6761-2998)
- Morgan F. Shaw
Institutions
- University of Exeter (GB)
- Royal Victoria Infirmary (GB)
- Newcastle upon Tyne Hospitals NHS Foundation Trust (GB)
- Freeman Hospital (GB)
- Newcastle upon Tyne Hospital (GB)
- Newcastle University (GB)
Publication Details
- Journal
- Diabetologia
- Published
- 2025-09-24
- DOI
- https://doi.org/10.1007/s00125-025-06547-8
- Citations
- 4
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 8.03
Funders
- University of Exeter
- Newcastle University